Official websites use. Share sensitive information only on official, secure websites. Long-chain Omega-3 polyunsaturated fatty acids Omega-3 PUFAs are widely recognized as powerful negative regulators of acute inflammation.
Particular attention is being focused also on their potential clinical application in chronic pathologies characterized by delayed and impaired healing, such as diabetes and vascular diseases in lower limbs.
On these bases, we firstly summarized the current knowledge on wound healing WH in skin, both in normal conditions and in the setting of these two pathologies, with particular attention to the cellular and molecular mechanisms involved. Then, we critically reviewed the outcomes of recent research papers investigating the activity exerted by Omega-3 PUFAs and their bioactive metabolites in the regulation of WH in patients with diabetes or venous insufficiency and showing chronic recalcitrant ulcers.
We especially focused on recent studies investigating the mechanisms through which these compounds may act. Considerations on the optimal dietary doses are also reported, and, finally, possible future perspectives in this area are suggested.
Keywords: diabetes, epigenetics, innate immune cells, microbiota, Omega-3 PUFA, venous leg ulcers, wound healing. For about thirty years, our main research interest was focused on the mechanisms underlying the anti-inflammatory and antineoplastic effects of the bioactive long chain Omega-3 polyunsaturated fatty acids LC Omega-3 PUFAs of dietary origin [ 1 , 2 , 3 , 4 ].
