Primary aldosteronism is the most common cause of endocrine hypertension and is associated with significant cardiovascular morbidities. The diagnostic workup depends on determinations of plasma aldosterone and renin which are highly variable and associated with false-positive and false-negative results. We aimed to establish an assay for urinary aldosterone and related steroids with suitability for clinical routine implementation.
Extraction recoveries were The reported assay is robust and suitable for routine clinical use. First results in patient samples, though promising, require clinical validation in a larger sample set. Funding source: Bayerische Forschungsstiftung. Funding source: Deutsche Forschungsgemeinschaft. Informed consent: Informed consent was obtained from all individuals included in this study.
Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission. Evidence for an increased rate of cardiovascular events in patients with primary aldosteronism.
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