Official websites use. Share sensitive information only on official, secure websites. The use, distribution or reproduction in other forums is permitted, provided the original author s and the copyright owner s are credited and that the original publication in this journal is cited, in accordance with accepted academic practice.
No use, distribution or reproduction is permitted which does not comply with these terms. The fouling resistance of zwitterionic coatings is conventionally explained by the strong hydrophilicity of such polymers. Here, the in vitro biocompatibility of a set of systematically varied amphiphilic, zwitterionic copolymers is investigated.
Photocrosslinkable, amphiphilic copolymers containing hydrophilic sulfobetaine methacrylate SPe and butyl methacrylate BMA were systematically synthesized in different ratios , , and with a fixed content of photo-crosslinker by free radical copolymerization.
The copolymers were spin-coated onto substrates and subsequently photocured by UV irradiation. Pure pBMA and pSPe as well as the prepared amphiphilic copolymers showed BMA content-dependent wettability in the dry state, but overall hydrophilic properties a fortiori in aqueous conditions. All polysulfobetaine-containing copolymers showed high resistance against non-specific adsorption NSA of proteins, platelet adhesion, thrombocyte activation, and bacterial accumulation.
In some cases, the amphiphilic coatings even outperformed the purely hydrophilic pSPe coatings. Keywords: polyzwitterion, antiadhesive, hydrogels, benzophenone methacrylate, platelet adhesion, thrombocyte activation.
