Official websites use. Share sensitive information only on official, secure websites. Correspondence: mouna. Wound healing consists of several continuous phases involving various cells and chemical intermediates. As a rich source of nutrition elements, honey has proved to have potential benefits in the treatment of various diseases. The present study was designed to investigate the healing effect of a honey mixture with selected essential oils on chemical and thermal wound models in rabbits.
Dressing mixtures of Thymus vulgaris honey with three essential oils Origanum vulgare, Rosmarinus officinalis, and Thymus vulgaris were prepared and applied daily in the treatment groups. These essential oils were rich in phytochemicals and had significant antibacterial activity against four selected ATCC bacterial strains. Madecasol ointment was used as a standard control. The healing effect of the mixtures was evaluated by measuring wound surface area and comparing healing time.
The results showed that the healing rate in the treatment groups was significantly higher than that of the untreated group and standard group. The best healing effect for burns was seen in the mixture of honey and Thymus vulgaris essential oil, which had wound closure rates of Therefore, it can be concluded that honey mixtures have significant beneficial effects on skin wound healing and, thus, they may be used as a healing agent in different types of wounds in humans after specific clinical trials.
Keywords: honey, essential oils, synergy, survey, toxicity, antimicrobial, wound healing, in vivo, rabbits. The skin is an exterior organ that covers the body and provides many vital functions, including organ protection, percutaneous absorption, body shape maintenance, fluid conservation, temperature control, and sensory and disease control [ 1 , 2 ].
Honey is a rich source of essential minerals and bioactive molecules with various therapeutic features [ 3 ]. For thousands of years, honey has been used in topical wound dressing [ 4 ]. The unique antibacterial, anti-inflammatory, and antioxidant properties of honey contributes to wound healing, especially in ulcers and burns [ 5 , 6 ]. A large number of publications in the twenty-first century evidenced the properties of honey in wound management and other medical applications of honey.
