Official websites use. Share sensitive information only on official, secure websites. The work cannot be changed in any way or used commercially without permission from the journal. A variety of complications after injection of nonpermanent fillers for facial rejuvenation have been reported so far. However, to date, the overall complication rate is still a matter of debate. The aim of this study was to perform a systematic review of literature to assess the type and severity of associated complications following injections in different anatomical regions of the face.
These complications have been reviewed and analyzed according to their occurrence in different anatomical regions of the face. Forty-six articles including a total of patients reported on a total of complications during the time period between January and February The most severe complications were observed in treatments of nose, glabella, and forehead.
Nonpermanent facial fillers are associated with rare but potentially severe complications. Severity and impact of complications depend on the anatomical region of the face and eventually require profound knowledge of facial anatomy. Nonpermanent fillers, including hyaluronic acid HA were officially introduced on the market in in Europe and 3 years later in the United States. Ever since, a massive diffusion has been observed to treat soft-tissue volume loss.
One of the reasons for this success is, among other things, a relatively easy access to the substance. Furthermore, nonpermanent fillers are relatively safe in terms of local immunological reaction, and are absorbable and presumably simple to administer.
HA is as polysaccharide naturally present in the human body as a component of the skin, the central nervous system, and blood vessels.
