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Early medical diagnostic in nanomedicine requires the implementation of innovative nanosensors with highly sensitive, selective, and reliable biomarker detection abilities.
Specifically, polydimethylsilane PDMS elastomer mold coated with a thin Au film employed for pattern replication of hexagonally close-packed monolayer of polystyrene nanospheres configuration has been employed as plasmonic nanoplatform to convey both SERS and LSPR readout signals, exhibiting both well-defined LSPR response and enhanced 3D electromagnetic field.
The development of such smart flexible healthcare nanosensor platforms holds promise for mass production, opening thereby the doors for the next generation of portable point-of-care devices. One of the top research priorities in nanomedicine is the implementation of nanotechnology-based diagnostics tools able to identify disease as early as possible, ideally at the level of a single molecule biomarker 1 , 2.
Early detection of specific disease biomarkers and effective diagnosis are important for disease screening, preventing epidemics and enabling physicians to provide the right therapy 3. Specifically, a large number of disease biomarkers are proteins and their presence in biological fluids are considered an indicator of the presence of some diseases such as diabetes, cancers and so on 4.
