Official websites use. Share sensitive information only on official, secure websites. Author contributions H. All authors reviewed and approved the manuscript. Psoriatic arthritis PsA is an inflammatory joint disease distinct from other chronic arthritides and frequently accompanied by psoriasis vulgaris PsV and seronegativity for rheumatoid factor.
These SNPs were also associated in a German psoriasis vulgaris cohort. Sequencing revealed coding variant p. Psoriasis vulgaris PsV is a common chronic inflammatory disease that affects the skin and is mediated by T-cells. A strong genetic component has been suggested by several studies, indicated for example by a relative risk of up to 40 for first degree and 12 for second degree relatives 3 , which suggests a stronger heritability than PsV 4.
However, knowledge of the genetic components contributing to PsV is more advanced than in PsA. After genotyping, stringent quality control and imputation of SNPs in linkage disequilibrium LD , 1,, SNPs in cases and controls were used in the analysis.
A quantile-quantile plot of the initial GWAS data showed substantial deviation from the expected distribution of genome-wide p-values for an unusually high number of SNPs Supplementary Fig.
At a third locus, two intronic variants rs, rs as well as one coding variant rs of the TRAF3IP2 gene, not previously reported to be involved in PsA susceptibility, were significantly associated 5. Genome wide association results from the initial GWAS analysis. Recombination rate from HapMap data is indicated by the light blue graph.
