Official websites use. Share sensitive information only on official, secure websites. Corresponding author. Hepatic encephalopathy HE is a frequent and severe complication in patients after transjugular intrahepatic portosystemic shunt TIPS insertion. Patients were retested after TIPS insertion. The majority of patients were male Median age was 59 years, model for end-stage liver disease score was 12, and Of note, mean performance in all tests remained stable over time after TIPS insertion.
We could not find evidence that TIPS insertion leads to a psychometric decline in the long term. This prospective observational study compared three diagnostic tests for mHE and showed the limited value of these tests for predicting overt HE in patients with cirrhosis undergoing TIPS insertion.
In addition, the results suggest that cognitive performance generally remains stable after TIPS insertion. These results are important for physicians and researchers involved in the management of patients with cirrhosis undergoing TIPS procedures.
The study's findings serve as a starting point for further investigations on the development of more effective strategies for predicting and managing post-TIPS HE. A total of 84 patients with cirrhosis underwent a minimal hepatic encephalopathy assessment before TIPS insertion. After TIPS insertion, they were monitored for days for the development of overt hepatic encephalopathy.
There was no significant association between pathological test results and overt hepatic encephalopathy post-TIPS. Patients were re-evaluated with all minimal hepatic encephalopathy tests at Months 1, 3, and 6 after TIPS insertion. The development of portal hypertension-related complications represents a hallmark in the natural course of patients with liver cirrhosis. To date, there are no established risk scores or tests that can reliably predict the occurrence of overt HE after TIPS insertion.
