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Aim: This study provided an overview of manipulating oral medicines given to hospitalised children and evaluated this practice in two hospitals. It focused on the type of manipulation and the dosage forms that were manipulated. Method: This was a cross-sectional, prospective study, carried out on the paediatric wards at two Norwegian hospitals for four weeks in A medicine was said to have been manipulated if it was not administered as described in the Norwegian summary of product characteristics.
Tablets, including modified release preparations, were the most frequently manipulated medicines. In approximately half of these cases, only a segment of the unit dose was administered. No manipulation of oral liquids was seen. Various routines for splitting and handling the unit doses were observed.
Conclusion: Manipulation of oral medication was regularly performed on paediatric wards. There is an urgent need for age-appropriate medicines, documented and standardised processes for manipulating medicines and staff training on the consequences of manipulation.
Keywords: Licenced medicine; Manipulation; Off-label prescribing; Oral medicine; Paediatrics. Abstract Aim: This study provided an overview of manipulating oral medicines given to hospitalised children and evaluated this practice in two hospitals. Substances Dosage Forms.